李枫 教授

职称职务：教授，博士/硕士研究生导师，系主任

学科专业：医学遗传学

研究方向：肿瘤靶向治疗

实验室位置：新葡的京集团350vip888811号楼

Email：fli222@whu.edu.cn

学习经历

1998.09~2002.07 华中农业大学，攻读学士学位

2002.09~2008.01 华中农业大学&中国科学院生物物理研究所联合培养，硕博连读

主要工作经历与任职

2008.04~2013.04 University of Kentucky College of Medicine, 博士后

2013.06~至今 武汉大学医学遗传学系，教授、博导

目前主要科学研究领域和兴趣

目前研究方向为肿瘤靶向治疗，鉴定新的靶点和提出新的治疗手段，包括

1. 基于肿瘤表观遗传和转录成瘾的协同致死机制研究；

2. 揭示肿瘤细胞关键生物大分子翻译后修饰的新功能；

教学情况

先后主讲过《医学遗传学》（中文/英文），细胞生物学，基础医学导论，博士英语等。参编国家卫计委“十三五”规划教材《医学遗传学(英文)》(人民卫生出版社)。

主要社会兼职

中国抗癌协会肿瘤标志物专业委员会青年委员会委员

湖北省医学会遗传学分会委员

Nature Communication, Cancer Research，Theranostics等专业期刊审稿人

代表性论文

1. Guanlan Fan#, Fan Wang#, Yurou Chen , Qian Zheng , Jie Xiong , Qiongying Lv , Kejia Wu , Jiaqiang Xiong , Lei Wei , Dongqing Li , Jiachen Zhang , Wei Zhang* and Feng Li* .The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region. Cell Reports, (2023), Jan 31;42(1):111916. 1区 Top, IF:9.95.

2. Qian Zheng#, Pengfei Li#, Xin Zhou, Yulong Qiang, Jiachen Fan, Yan Lin, Yurou Chen, Jing Guo, Fan Wang, Haihua Xue, Jie Xiong* and Feng Li*. Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis. Theranostics ,(2021) 11(18): 8674-8691. 1区 Top, IF:11.55.

3．Chen X#, Zhao B#, Qu Y, Chen Y, Xiong J, Feng Y, Men D, Huang Q, Liu Y, Yang B, Ding J and Feng Li*. Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019；Clinical Infectious Disease. (2020) 71(8):1937–42. 1区Top,  IF:22 注: 该研究为SCI高被引论文。

4. 向莹,熊洁,李枫* 肿瘤细胞中染色质修饰与代谢的相互调控, 肿瘤代谢与营养电子杂志 , 2019年12月9日第6卷第4期.

5. Ying Xiang, Kai Yan, Qian Zheng, Haiqiang Ke, Jie Cheng, Wenjun Xiong, Xin Shi, Lei Wei, Min Zhao, Fei Yang, Ping Wang, Xing Lu, Li Fu, Xuemei Lu*, and Feng Li*.Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1. Cancer Research, (2019),79(1),86-98. 1区 Top, IF:12.7.

6. Xiaohua Chen, Loo JX, Shi X, Xiong W, Guo Y, Ke H, Yang M, Jiang Y, Xia S, Zhao M, Zhong S, He C, Fu L, and Feng Li*. E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the EGFR and c-MET Oncogenes by Destabilizing the Histone Demethylase KDM5C, Cancer Research, (2018),78(6),1418-1430. 1区 Top, IF:12.7.  

7. Feng Li, J.Ortega, B.Peng, Gu, L., and Li,G.M*. Regulation of Mismatch Repair by Histone Code and Posttranslational Modifications in Eukaryotic Cells (Review). DNA Repair, (2016), 68–74. 2区, IF:4.91

8. Feng Li, Mao, G.G., Tong, D., Huang,J., Gu, L. *, and Li,G.M*, The histone mark H3K36me3 regulate human mismatch repair through its interaction with MutSalpha, Cell, 2013, 153, 590–600, 1区Top，IF:41.58  注：该论文入选F1000，Cell邀请同行权威在同一期撰写leading edge preview; Nature Review, Nature Genetics和Cancer Discovery均予以点评和推荐；Cell为自然指数（Nature index）期刊